Fibroblast-directed expression and localization of 92-kDa type IV collagenase along the tumor-stroma interface in an in vitro three-dimensional model of human squamous cell carcinoma

1997 ◽  
Vol 19 (4) ◽  
pp. 258-266 ◽  
Author(s):  
Alexander H. Borchers ◽  
Heinrich Steinbauer ◽  
Birgit S. Schafer ◽  
Michael Kramer ◽  
G. Tim Bowden ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Three Dimensional ◽  
Tumor Stroma ◽  
Dimensional Model ◽  
Three Dimensional Model ◽  
Type Iv Collagenase ◽  
Human Squamous Cell Carcinoma ◽  
Type Iv

Inhibitory effect of resveratrol on the growth and angiogenesis of human endometrial tissue in an In Vitro three-dimensional model of endometriosis

2020 ◽  
Vol 20 (4) ◽  
pp. 484-490
Author(s):  
Mohammad Rasool Khazaei ◽  
Zahra Rashidi ◽  
Farzaneh Chobsaz ◽  
Elham Niromand ◽  
Mozafar Khazaei
Keyword(s):  
Three Dimensional ◽  
Inhibitory Effect ◽  
Endometrial Tissue ◽  
Dimensional Model ◽  
Three Dimensional Model

scholarly journals Diclofenac-Derived Hybrids for Treatment of Actinic Keratosis and Squamous Cell Carcinoma

Molecules ◽  
2019 ◽  
Vol 24 (9) ◽  
pp. 1793 ◽  
Author(s):  
Silvia Tampucci ◽  
Sara Carpi ◽  
Maria Digiacomo ◽  
Beatrice Polini ◽  
Stefano Fogli ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Actinic Keratosis ◽  
Antiproliferative Activity ◽  
Human Squamous Cell Carcinoma ◽  
Self Assembling ◽  
Ak Model ◽  
New Treatments

In this work, hybrid compounds 1–4 obtained by conjugation of the non-steroidal anti-inflammatory drug diclofenac, with natural molecules endowed with antioxidant and antiproliferative activity were prepared. The antiproliferative activity of these hybrids was evaluated on immortalized human keratinocyte (HaCaT) cells stimulated with epidermal growth factor (EGF), an actinic keratosis (AK) model, and on human squamous cell carcinoma (SCC) cells (A431). Hybrid 1 presented the best activity in both cell models. Self-assembling surfactant nanomicelles have been chosen as the carrier to drive the hybrid 1 into the skin; the in vitro permeation through and penetration into pig ear skin have been evaluated. Among the nanostructured formulations tested, Nano3Hybrid20 showed a higher tendency of the hybrid 1 to be retained in the skin rather than permeating it, with a desirable topical and non-systemic action. On these bases, hybrid 1 may represent an attractive lead scaffold for the development of new treatments for AK and SCC.

Antitproliferative effects of citrus flavonoids on a human squamous cell carcinoma in vitro

1991 ◽  
Vol 56 (2) ◽  
pp. 147-152 ◽  
Author(s):  
C. Kandaswami ◽  
E. Perkins ◽  
D.S. Soloniuk ◽  
G. Drzewiecki ◽  
E. Middleton
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Human Squamous Cell Carcinoma ◽  
Citrus Flavonoids

In vitro evaluation of Taxol® combined with radiations in human squamous cell carcinoma spheroids

1996 ◽  
Vol 109 (1-2) ◽  
pp. 23-32 ◽  
Author(s):  
Genevieve Griffon-Etienne ◽  
Jean-Louis Merlin ◽  
Christian Marchal
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
In Vitro Evaluation ◽  
Human Squamous Cell Carcinoma

scholarly journals Mutagenesis and Molecular Modeling Reveal Three Key Extracellular Loops of the Membrane Receptor HasR That Are Involved in Hemophore HasA Binding

2007 ◽  
Vol 189 (14) ◽  
pp. 5379-5382 ◽  
Author(s):  
Clément Barjon ◽  
Karine Wecker ◽  
Nadia Izadi-Pruneyre ◽  
Philippe Delepelaire
Keyword(s):  
Molecular Modeling ◽  
Outer Membrane ◽  
Three Dimensional ◽  
Membrane Receptor ◽  
Dimensional Model ◽  
Outer Membrane Receptor ◽  
Three Dimensional Model ◽  
Extracellular Loops

ABSTRACT On the basis of the three-dimensional model of the heme/hemophore TonB-dependent outer membrane receptor HasR, mutants with six-residue deletions in the 11 putative extracellular loops were generated. Although all mutants continued to be active TonB-dependent heme transporters, mutations in three loops abolished hemophore HasA binding both in vivo and in vitro.

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